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str.translate(table)
bytes.translate(table[, delete])    
bytearray.translate(table[, delete])

#!/usr/bin/python3

intab = "aeiou"
outtab = "12345"
trantab = str.maketrans(intab, outtab)   # Create translation table

str = "this is string example....wow!!!"
print (str.translate(trantab))

th3s 3s str3ng 2x1mpl2....w4w!!!

#!/usr/bin/python

# Create translation table
bytes_tabtrans = bytes.maketrans(b'abcdefghijklmnopqrstuvwxyz', b'ABCDEFGHIJKLMNOPQRSTUVWXYZ')

# Convert to uppercase and remove letter 'o'
print(b'tutorialpro'.translate(bytes_tabtrans, b'o'))

b'RUNB'