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list_1 = [1, 2, 1, 4, 6]

print(list(set(list_1)))

[1, 2, 4, 6]

list_1 = [1, 2, 1, 4, 6]
list_2 = [7, 8, 2, 1]

print(list(set(list_1) ^ set(list_2)))

[4, 6, 7, 8]