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string.maketrans(x[, y[, z]])

#!/usr/bin/python3

# Replace letter R with N
txt = "tutorialpro!"
mytable = txt.maketrans("R", "N")
print(txt.translate(mytable))

# Set characters to be replaced, one-to-one
intab = "aeiou"
outtab = "12345"
trantab = str.maketrans(intab, outtab)

str = "this is string example....wow!!!"
print (str.translate(trantab))

Nunoob!
th3s 3s str3ng 2x1mpl2....w4w!!!

#!/usr/bin/python3

txt = "Google tutorialpro Taobao!"
x = "mSa"
y = "eJo"
z = "odnght"   # Set characters to be removed
mytable = txt.maketrans(x, y, z)
print(txt.translate(mytable))

Gle Rub Tobo!